Synthesis and antimicrobial activity of new bridgehead nitrogen compounds

This study reported the preparation of some new bridgehead nitrogen compounds using the beta-keto ester and indane-1,3-dione with 3-amino- 1,2,4-triazole and aminobenzimidazole

Enamine rearrangement of pyrimidinium salts Part XI: Novel synthesis of some pyrazolo and triazolopyrimidine derivatives

The pyrazolo [1,5-a] pyrimidine derivatives IV and VI underwent pyrimidine ring opening, then recyclized when heated with aqueous alcoholic alkali solution to give the corresponding pyrazolo [3,4-b] pyridine V and VII, respectively. In a similar manner, the triazolo [4,3-a] pyrimidine VIII underwent recyclization to the corresponding triazolo [1,5-a] pyrimidine IX

Reaction of biindone with amines and diazonium salts

The biindone I reacted with morpholine or piperidine and formaldehyde to give the corresponding Mannich bases IIa-b. Treatment of I with formaldehyde, and formaldehyde in AcOH, afforded II and IV, respectively. Compounds V and VI were prepared by treating I with benzaniline and isatinanil, respectively. Coupling of I with benzenediazonium chloride led to the formation of VII

Enamine rearrangement of pyridinium salts part XII rearrangement of 2-alkylpyrimidines to 2-aminopyridines

In alcoholic methylamine solution, 2-alkylpyrimidines underwent rearrangement to 2-methylaminopyridines. Similarly, in alkaline medium, even a nonquaternized 2-methyl-5-nitropyrimidine formed 2-amino-5-nitropyridine